Pseudoangiomatous Hyperplasia of Mammary stroma (PHMS), as tumor mass, is a rare benign stromal lesion, recently described. PHMS on microscopic examination should not be misdiagnosed as angiosarcoma.

We report two cases of 36 and 40 years old women with a palpable, painful, breast mass. In mammography the lesions were quite well demarcated, measuring 3 and 2,5 cm in diameter. On microscopic examination they were composed of intermixed stromal and epithelial elements. The characteristic stroma, in inter-and intralobular distribution, was collagenous, Keloid or edematous containing many clefts and anastomosing empty spaces. The cells lining the pseudoangiomatous spaces exchibited strong immunoreactivity for Vimentin, Anti-muscle Actin, and were negative for factor VIII or Ulex Europaeus. These findings are keeping with the current acceptance of the lining cells as fibroblasts confirming that the lesion represents a localised form of a reactive stromal overgrowth.

Key-Words: Hyperplasia, Stromal, Pseudoangiomatous, Breast

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Hellenic Archives of Pathology, 1994, 8(3): 161-165