Lipophyllodes tumor of the breast with multinucleated
stromal giant cells
Tzaida O.1, Arapantoni-Dadioti
P.3, Katsiki B.2,
Zobolas B.2, Polychronis A2
1Dept. of Social Services
Oncological Hospital "G. Gennimatas" Pathology Dept. & 2Surg.
Breast Clinic, 3Pathology Dept.
"Metaxa" cancer Hospital
A benign fibroepithelial neoplasm of the mammary gland with multinuucleated stromal giant cell, in 39 year old woman, is presented. The
lesion was a palpable, freely movable, rather circumscribed, painless,
solitary mass with lobulated cut surface measuring 2,5 cm in
greatest dimension. As the tumor microscopicalIy presented a variety
of histologic features including those of fibroadenoma, hamartoma
and lipophyllodes tumor, its final classification was difficult.
Another unusual and further confusing finding was the presence
of numerous multinucleated giant cells in its stroma. Most of
these cells considered as part of a benign reactive process and
the remaining as atypical lipocytes. The diagnosis of a benign
neoplasm without malignant transformation was based on the absence
of the cardinal histologic findings of malignancy for these type
of tumors (e.i. cellularity and stromal overgrowth, mitotic activity
necrosis and infiltrating borders). The multinucleated giant
cells of the reactive type, confined to the stroma of an otherwise
benign neoplasm, should not be misinterpreted by the pathologist
as evidence of malignancy.
Key words: Lipophyllodes tumor, breast.
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