Α case of Chronic Granulomatous disease with lung involvement in a 11 years old boy is described. The disease was presented with persistent fever despite antibiotic treatment, and a circumscribed lesion of the upper lobe of the right lung. Histologically there was the picture of a necrotizing granulomatous bronchopneumonia. The diagnosis of Chronic Granulomatous disease was confirmed by a completely negative reduction of NBT dye in patients neutrophils. Western blot analysis showed a clear deficiency of the p47-phox component of the NADPH oxidase enzyme of his neutrophils but a normal expression in the cells from his parents. These results indicate the autosomal recessive form of genetic transmission of the disease.

Key words: Chronic Granulomatous disease, dysfunction, neutrophils, lung.

Full text in Greek