Immunohistochemical study of the Lactoferrin, Ceruloplasmin
and Secretory Component Expression in neoplastic and non-neoplastic
thyroid gland diseases
Kondis-Paphitis A., Kairi-Vassilatou E., Carvounis H., Frangou-Plemmenou
Matrona, Kontoyanni K., Deligeorgi-Politi H.
Pathology Department, Areteion University Hospital Athens Greece
The aim of this study is to investigate the expression of Lactoferrin
(LF). Ceruloplasmin (CP), and Secretory Component (SC) in various
thyroid gland diseases. LF is an iron-binding glucoprotein overexpressed
in certain human adenocarcinomas. CP is implicated in carcinogenesis
and Sc is part of the Iocal immunological defense system. Their
expression in thyroid neoplasms is not yet widely investigated
as well as the possibility that they may be a useful aid in the
differential diagnosis between benign and malignant thyroid diseases.
Sections of 15 follicular adenomas, 5 follicular carcinomas, 16
papillary carcinomas, 15 goitres and 2 cases of lymphocytic thyroiiditis
were reexamined and were immunohistologically investigated by
a streptavidinbiotin method for LF, Cp, SC and thyroglobulin.
All follicular and papillary thyroid carcinomas were positive
for LF, CP and strongly positive for SC. Hurthle cells in thyroiiditis
were positive for SC. Non-neoplasmatic diseases gave negative
reaction. In conclusion, the expression of LF, CP and SC are a
valuable diagnostic aid in the d.d. between benign and malignant
thyroid tumors. The expression of SC shows the presence of a local
immunological defence system.
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