A case of a rare, recently described, variant of ductal breast carcinoma exhibiting distinct pathologic features, is presented. The patient, an elderly 80 years old woman, presented with a palpable mass in the subareolar area accompanied by nipple discharge. Mamography revealed a prominent duct pattern with irregular density without suspicious microcalcifications. A wide excisional biopsy showed a firm lesion, measuring 5 cm in maximum diameter, with presence of numerous, variably sized cysts measuring up to 1,5 cm, filled with a gelatinous-mucinous material. Microscopically the most striking feature was the dilatation of the duct system containing an eosinophilic, homogeneous, virtually acellular secretion reminiscent of thyroid colloid. Although some of the former cysts were lined by a benign-appearing flattened or single layered cuboidal or collumnar epithelium, others showed a multilayered lining of atypical ductal epithelial cells with progression to intraductal clinging or micropapillary carcinoma in many areas. The rarity of CHDC and its deceptively bland low-power appearance that may be confused with a variety of benign breast diseases, prompted us to present this particular type of carcinoma.

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