Solitary fibrous tumor is an unusual spindle cell proliferation, most often seen in the pleura and other serosa-lined organs. More recent work has demonstrated identical lesions in locations unrelated to serosal surfaces, as well as better characterized the immunohistochemical profile and the differential diagnosis of this entity. We present two previously unreported cases, with identical histopathologic, immunohistochemical and ultrastructural features, arising in the soft tissues. We believe that these cases represent two additional examples of the recently described solitary fibrous tumor of the soft tissues. Most of the time these lesions are benign and simple excision should be curative. However, malignant examples have been documented. The differential diagnosis is discussed and relevant MEDLINE-referenced literature is reviewed.

Key words: Solitary fibrous tumor, soft tissues, CD34.

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