Cardiac myxomas-Immunohistochemical study
Iordanidis F., Tzarou V., Asimaki A., Basarat H.,
Kariki E., Sakkas L., Skordalaki A.
Department of Pathology,
General Hospital "G. Papanikolaou", Thessaloniki
Aim: Evaluation of the clinicopathological parameters
combined with immunohistochemical studies of cardiac myxomas in
an attempt to investigate the possible histogenesis of these tumors.
Material and Methods: Thirty cardiac myxomas
were retrieved from the files of Pathology Department of G. Papanikolaou
General Hospital-Thessaloniki. These were reevaluated using as
parameters the location, tumor size, age, sex and clinical findings.
Furthermore, antibodies to vimentin, a-smooth muscle actin (SMA),
S-100 protein, calretinin, factor VIII, CD-34, keratin (AE1/AE3)
and CD-117 (c-kit) were applied and studied.
Results: The cells were positive to vimentin
(100%), calretinin (86%), CD-34 (73%), factor VIII (43%), a-smooth
muscle actin (SMA) and S-100 protein (26%), while were negative
to keratin (AE1/AE3) and CD-117 (c-kit).
Conclusions: The positivity of cells to vimentin
indicates a mesenchymal origin, to calretinin shows neural differnetiation
and to CD-34 and factor VIII endothelial differentiation. The
results of our study are in agreement with those of international
bibliography but the histogenetic origin of these tumors is still
debatable and needs further investigation.
Key words: Çeart, myxoma, histogenesis, immunohistochemistry.
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