Neoangiogenesis in gallbladder carcinoma
Kalekou Chariklia, Miliaras Dimosthenis, Kamas Athanasios
Dept of Pathology, St Paul General Hospital of Thessaloniki
The aim of this study is the investigation of the association
between the microvessel density(MVD) in the stroma of gallbladder
carcinomas with the depth of invasion, the degree of differentiation
and the expression of p53 protein and cerbB2 oncogene protein
expression by the tumor cells. Immunohistochemical staining with
antibodies against FactorVIIIRAg, p53 protein and c-erbB2 were
performed on sections from 33 cases of gallbladder carcinoma.
Significant increase of MVD was found with increasing depth of
invasion (p<0.02). No association of MVD with degree of differentiation
and p53 and c-erbB2 protein expression was shown. The expression
of p53 protein was significantly higher in advanced stage tumors
(p=0.028) and in moderately and well differentiated tumors (p<0.05).
It is concluded that MVD in carcinomas of the gallbladder increases
progressively with increasing tumor invasiveness. This process
appears to be unrelated with the expression of the c-erbB2 and
p53 gene product. Both MVD increase and p53 protein expression
seem to play a significant role in gallbladder carcinoma progression
and to be associated with increased tumor aggressiveness.
Key words: Neoangiogenesis, gallbladder carcinoma, p53
protein, FVIIRAg, cerbB2.
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