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Hellenic Archives of Pathology, Volume 21, Issues 1-3, 2007, 48-52
Carcinosarcoma of the upper respiratory tract.
A case report
Chatzipantelis P., Kafiri G., Priftis D., Stefanadi Å., Papadimitriou Ê.
Department of Pathology, General Hospital of Athens «Hippokration»
We report the case of a 52-year-old male patient, admitted in our hospital with a tumor in the left cervical area. Excision of the tumor and cervical lymphadenectomy were performed; the histological examination revealed a metastatic poorlydifferentiated squamous-cell carcinoma. The same patient had recurrences after 4 and 4.5 years at the base of the tongue. Histological and immunohistolochemical examination revealed a spindle-cell carcinosarcoma in both cases. Six months later, two recurrences emerged in the laryngeal epiglottal area and oral cavity, which led to total laryngectomy. Histological examination revealed a poorly-differentiated neoplasm with increased cellularity consisting of large spindle-cells with brisk mitotic activity; their immunophenotype was consistent with a neoplasm of mesenchymal origin. In the consecutive recurrences, the primary neoplasm was even less differentiated, whereas in the last one it underwent total mesenchymal metaplasis to smooth muscle cells.
Key words: Upper aerodigestive tract, spindle-cell carcinosarcoma.
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