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Hellenic Archives of Pathology, Volume 22, Issues 1-3, 2008, 15-32
p53 role in the deregulated overexpression of E2F1
in osteosarcomas
Liontos Ì.1, Niforou Ê.1, Vougas Ê.2, Evangelou Ê.1, Apostolopoulou Ê.1, Kotsinas Á.1, Kontovazenitis Ê.1, Velimezi G.1, Drougou Á.1,3, Kyparidou Å.4, Thoma-Tsaglis Å.5, Âarbatis C.3, Tsangaris G.T.2, Papavasiliou A.G.6, Kittas C.1, Gorgoulis V.G.1
1Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, University of Athens,
2Division of Biotechnology, Centre of Basic Research II, Foundation for Biomedical Research of the Academy of Athens,
3Department of Pathology, "Korgialenio-Mpenakio" Hospital, Greek Red Cross, Athens,
42nd Department of Pathology, Konstantopoulio General Hopital, Athens,
5Department of Pathology, Asklepeion Voula Hospital, Athens,
6Department of Biochemistry, School of Medicine, University of Athens
The aim of the present study is the in vivo and in vitro investigation of the correlation between E2F1 and osteosarcoma kinetics, as well as of the cellular response after E2F1 overexpression. Based on the results it is suggested that p53 is a central regulator of E2F1 expression regarding the osteosarcoma kinetics. The overexpression of E2F1 finally leads to activation of p53.
Key words: Osteosarcoma, E2F1, proteomics.
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