A case of nodular regenerative hyperplasia (NRH) of the liver in a 41 year old man presenting with symptoms of rheumatic disease and mild hepatic dysfunction, is described. NRH is characterized by diffuse presence of parenchymal nodules, compression atrophy of the parenchyma between the nodules and Iack of fibrosis. Although the aetiology remains obscure, this hepatic lesion has been reported in association with a variety of benign and malignant diseases both in adults and in children. Open surgical biopsy is reecommended in the literature rather than needle biopsy of the liver which may cause diagnostic difficulties due to its small size. The importance of the diagnosis lies in the elucidation of the underlying hepatic pathology in cases of liver dysfunction with or without portal hypertension. Cases associated with drug intake, such as anabolic steroid treatment, may benefit from discontinuation of the treatment.

Key words: Nodular, hyperplasia, liver.

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