Prognostic significance
of DNA ploidy in human neoplasms
N. Kapranos, E. Kontogiannis, H. Karantasis
Dpt of Pathology, Division of Molecular Pathology,
Amalia Fleming Hospital, Athens, Greece
In modern pathology is recognized the importance
of more accurate information regarding the biologic behavior and
prognosis of the neoplasms. Genetic changes are the basic characteristics
of the multistep process of carcinogenesis which comprise complex
gene and chromosomal abnormalities. Flow cytometry and image analysis
of system are the two basic cytophotometric techniques for the
quantitative analysis of cellular DNA content which is expressed
as DNA ploidy. Using these cytophotometric systems a lot of studies
have been performed assessing the value of cellular DNA content
alterations for the biologic behavior of the various human tumors.
In this paper the most important findings of the medical literature
for almost every human tumor type is reviewed, with special emphasis
on the impact of DNA ploidy for patient prognosis.
Key words: Cytophotometry, DNA ploidy, flow cytometry,
Image analysis system, neoplasms, prognosis.
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