Acinic cell adenocarcinoma: A clinicopathological
study
O. Tzaida, V. Leodara, I. Iakovidou,
G. Sotiropoulou, P. Arapantoni-Dadioti
Pathology Department, Metaxas Cancer Hospital of Pireaus
Seven cases of acinic cell adenocarcinoma, a neoplasm with distinct
clinicopathological features, diagnosed in our laboratory during
a period of 10 years, are presented. Six cases were salivary gland
tumors, which in our material constitute the second more common
neoplasm of these organs. Five out of six tumors, were located
in the parotid gland, which is the main site of their development
and the sixth in a minor salivary gland of the lower lip. An additional
case of a primary salivary gland- type pulmonary tumor which presented
as an endobronchial mass was included in our study. The patients'
age was 76-, 71-, 56-, 50-, 28- and 60-years and the greatest
tumor diameter varied from 0.6 to 1.5 cm. Histologically, all
neoplasms had typical morphological features consistent with acinic
cell adenocarcinoma. Acinic cell adenocarcinoma is a neoplasm
with a rather indolent biological course, in spite of its metastatic
potential which is responsible for the prevalence of the term
“carcinoma” instead of that of “tumor”. A broad histological and
immunohistochemical investigation was performed confirming the
diagnosis and the low malignant potential of the tumors. A review
of the available literature is reported.
Key words: Acinic, adenocarcinoma, parotid, salivary gland,
lung, Fechner tumor.
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