Rheumatology Case 3

A 55 year old woman with a history of “bronchial asthma”, recurrent iritis and articular chondritis presented with a high fever. Clinical examination revealed a dyspnoiec patient with a moon face and a saddle-shaped nose with diffuse wheezing bilaterally over the lungs. Laboratory evaluation showed leukocytosis with polymorphonuclearcytosis, high ESR, high CRP, and negative ANCA. The chest X-ray was normal. The differential diagnosis consists of:
1. Relapsing polychondritis
2. Cogan’s syndrome  
3. Wegener's granulomatosis  
4. Systemic vasculitis (Churg-Strauss syndrome)  

 
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